• The Formula Guide

Find your formula.

GLP-1 medications create specific gaps in your body. Each Semante formula closes one of them. Find which ones apply to you.

What is your GLP-1 costing you?

01Situation 01

Your weight loss is stalling.

GLP-1 receptor agonists work by activating AMPK — the metabolic master switch that regulates glucose uptake, fat oxidation, and insulin sensitivity. Over time, as your body adapts to the medication, this signal weakens. The result is a plateau that more medication doesn't always solve. Berberine HCl activates the same AMPK pathway through a completely independent mechanism — compounding the effect of your prescription rather than duplicating it. At 800mg, it's the dose the clinical literature actually studied.

This is addressed by →

Vol. 01 — Amplify

02Situation 02

You're losing muscle, not just fat.

This is the most underreported consequence of GLP-1 therapy. Clinical studies tracking semaglutide users found that up to 40% of total weight lost came from lean mass — muscle, bone, and organ tissue — rather than fat. Your medication cannot distinguish between the two. Creatine monohydrate at 5,000mg is the most studied muscle-preservation compound in existence, with over 500 peer-reviewed trials supporting its efficacy. It works by maintaining phosphocreatine stores in muscle tissue — the primary fuel source for intense muscular contractions. The electrolyte blend addresses the cellular dehydration that accelerates during rapid weight loss, restoring the ionic balance your muscles need to function and recover.

This is addressed by →

Vol. 02 — Preserve

03Situation 03

Your hair is thinning and your energy is low.

Telogen effluvium — clinically documented hair shedding triggered by physiological stress — is one of the most commonly reported side effects among GLP-1 users. It typically appears three to five months into treatment, long after most people have stopped connecting it to their medication. The mechanism is nutritional: rapid weight loss reduces food intake, which reduces micronutrient availability across the board. Biotin, folate, and vitamin D3 are the three nutrients most directly implicated in keratin infrastructure and hair follicle cycling. The problem with standard biotin capsules is bioavailability — digestion destroys a significant portion before absorption. Restore delivers 10,000mcg of biotin as a sublingual oral strip, absorbed directly through the mucous membrane under the tongue, bypassing the gastrointestinal tract entirely.

This is addressed by →

Vol. 03 — Restore

• The Formulas

Three formulas. Each one built for a specific gap.

Vol. 01

Amplify

For the metabolic signal.

What's in it

Berberine HCl800mg

Activates AMPK — the same metabolic pathway your GLP-1 medication targets. Studied at this exact dose in human trials for glucose regulation and insulin sensitivity.

Black Pepper Extract (Bioperine)5mg

Increases bioavailability of berberine by up to 20%. Without it, a significant portion passes through unabsorbed.

Who it's for

Anyone experiencing a weight loss plateau, inconsistent blood sugar levels, or reduced response to their GLP-1 medication after the initial months of treatment.

$49or $39/mo

Shop Amplify →

Vol. 02

Preserve

For the muscle and energy.

What's in it

Creatine Monohydrate5,000mg

The most peer-reviewed muscle-preservation compound in sports science. Maintains phosphocreatine stores in muscle tissue during caloric deficit — exactly the condition GLP-1 therapy creates.

Electrolyte BlendProp. blend

Rapid weight loss accelerates electrolyte depletion. This blend restores sodium, potassium, and magnesium — the three ions most critical for cellular hydration and muscle function.

Who it's for

Anyone noticing reduced strength, increased fatigue, poor workout recovery, or visible muscle loss alongside their weight reduction on GLP-1 therapy.

$44or $35/mo

Shop Preserve →

Vol. 03

Restore

For what weight loss takes.

What's in it

Biotin (as D-Biotin)10,000mcg

The clinically relevant dose for hair follicle support. Delivered as a sublingual strip — absorbed through the mucous membrane directly, bypassing digestion entirely. Standard capsules lose a significant portion to gastrointestinal breakdown.

Sublingual Delivery System—

The strip format is the entire point. Oral bioavailability of sublingual delivery is meaningfully higher than standard oral supplementation for water-soluble vitamins.

Who it's for

Anyone experiencing hair thinning, increased shedding, brittle nails, or fatigue that began three to five months into GLP-1 treatment.

$40or $32/mo

Shop Restore →

• The Complete Protocol

Not sure which one? Take all three.

Most people on GLP-1 therapy are experiencing more than one of these situations simultaneously. The Full Stack combines all three formulas into a single monthly protocol — Amplify, Preserve, and Restore — at a price that reflects the commitment.

Vol. 01 — AmplifyVol. 02 — PreserveVol. 03 — Restore

$79/moThree formulas. One protocol.

Shop The Full Stack →

• A note on our standards

Every ingredient in every Semante formula is dosed at the level studied in published human clinical trials. We do not use proprietary blends to obscure underdosing. We do not add ingredients to make labels look impressive. If the research supports a dose, that is the dose we use. If the research does not exist at a meaningful level, the ingredient does not appear in our formulas.

Read the research in our Journal →

Still not sure which formula is right?

Take the Fit Check →Contact Us →